A Multivariate Twin Study of Hippocampal Volume, Self-Esteem and Well-Being in Middle Aged Men
Identifieur interne : 000742 ( Main/Exploration ); précédent : 000741; suivant : 000743A Multivariate Twin Study of Hippocampal Volume, Self-Esteem and Well-Being in Middle Aged Men
Auteurs : Thomas S. Kubarych ; Elizabeth C. Prom-Wormley ; Carol E. Franz [États-Unis] ; Matthew S. Panizzon [États-Unis] ; Anders M. Dale [États-Unis] ; Bruce Fischl ; Lisa T. Eyler ; Christine Fennema-Notestine [États-Unis] ; Michael D. Grant ; Richard L. Hauger [États-Unis] ; Dirk H. Hellhammer [Allemagne] ; Amy J. Jak [États-Unis] ; Terry L. Jernigan [États-Unis] ; Sonia J. Lupien [Canada] ; Michael J. Lyons ; Sally P. Mendoza ; Michael C. Neale ; Larry J. Seidman [États-Unis] ; Ming T. Tsuang [États-Unis] ; William S. Kremen [États-Unis]Source :
- Genes, Brain, and Behavior [ 1601-1848 ] ; 2012.
Abstract
Self-esteem and well-being are important for successful aging, and some evidence suggests that self-esteem and well-being are associated with hippocampal volume, cognition, and stress responsivity. Whereas most of this evidence is based on studies of older adults, we investigated self-esteem, well-being and hippocampal volume in 474 male middle-age twins. Self-esteem was significantly positively correlated with hippocampal volume (.09, p=.03 for left hippocampus, .10, p=.04 for right). Correlations for well-being were not significant (ps ≫.05). There were strong phenotypic correlations between self-esteem and well-being (.72, p<.001) and between left and right hippocampal volume (.72, p<.001). In multivariate genetic analyses, a 2-factor AE model with well-being and self-esteem on one factor and left and right hippocampal volumes on the other factor fit the data better than Cholesky, independent pathway or common pathway models. The correlation between the two genetic factors was .12 (p=.03); the correlation between the environmental factors was .09 (p>05). Our results indicate that largely different genetic and environmental factors underlie self-esteem and well-being on the one hand and hippocampal volume on the other.
Url:
DOI: 10.1111/j.1601-183X.2012.00789.x
PubMed: 22471516
PubMed Central: 3389179
Affiliations:
- Allemagne, Canada, États-Unis
- Californie, Massachusetts, Québec, Rhénanie-Palatinat
- Cambridge (Massachusetts), Montréal, San Diego, Trèves (Allemagne)
- Université Harvard, Université McGill, Université de Trèves
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Kubarych</name><affiliation><nlm:aff id="A1">Department of Psychiatry, Virginia Commonwealth University</nlm:aff><wicri:noCountry code="subfield">Virginia Commonwealth University</wicri:noCountry></affiliation></author><author><name sortKey="Prom Wormley, Elizabeth C" sort="Prom Wormley, Elizabeth C" uniqKey="Prom Wormley E" first="Elizabeth C." last="Prom-Wormley">Elizabeth C. Prom-Wormley</name><affiliation><nlm:aff id="A1">Department of Psychiatry, Virginia Commonwealth University</nlm:aff><wicri:noCountry code="subfield">Virginia Commonwealth University</wicri:noCountry></affiliation><affiliation><nlm:aff id="A12">Department of Human Genetics, Virginia Commonwealth University</nlm:aff><wicri:noCountry code="subfield">Virginia Commonwealth University</wicri:noCountry></affiliation></author><author><name sortKey="Franz, Carol E" sort="Franz, Carol E" uniqKey="Franz C" first="Carol E." last="Franz">Carol E. Franz</name><affiliation wicri:level="3"><nlm:aff id="A2">Department of Psychiatry, University of California, San Diego</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Diego</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Psychiatry, University of California</wicri:orgArea></affiliation><affiliation wicri:level="3"><nlm:aff id="A14">Center for Behavioral Genomics, University of California, San Diego</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Diego</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Center for Behavioral Genomics, University of California</wicri:orgArea></affiliation></author><author><name sortKey="Panizzon, Matthew S" sort="Panizzon, Matthew S" uniqKey="Panizzon M" first="Matthew S." last="Panizzon">Matthew S. Panizzon</name><affiliation wicri:level="3"><nlm:aff id="A2">Department of Psychiatry, University of California, San Diego</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Diego</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Psychiatry, University of California</wicri:orgArea></affiliation></author><author><name sortKey="Dale, Anders M" sort="Dale, Anders M" uniqKey="Dale A" first="Anders M." last="Dale">Anders M. Dale</name><affiliation wicri:level="3"><nlm:aff id="A3">Department of Radiology, University of California, San Diego</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Diego</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Radiology, University of California</wicri:orgArea></affiliation><affiliation wicri:level="3"><nlm:aff id="A4">Department of Neurosciences, University of California, San Diego</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Diego</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Neurosciences, University of California</wicri:orgArea></affiliation></author><author><name sortKey="Fischl, Bruce" sort="Fischl, Bruce" uniqKey="Fischl B" first="Bruce" last="Fischl">Bruce Fischl</name><affiliation><nlm:aff id="A5">Department of Radiology, Harvard Medical School and Massachusetts General Hospital</nlm:aff><wicri:noCountry code="subfield">Harvard Medical School and Massachusetts General Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Eyler, Lisa T" sort="Eyler, Lisa T" uniqKey="Eyler L" first="Lisa T." last="Eyler">Lisa T. Eyler</name><affiliation><nlm:aff id="A1">Department of Psychiatry, Virginia Commonwealth University</nlm:aff><wicri:noCountry code="subfield">Virginia Commonwealth University</wicri:noCountry></affiliation><affiliation><nlm:aff id="A6">VA San Diego Health Care System</nlm:aff></affiliation></author><author><name sortKey="Fennema Notestine, Christine" sort="Fennema Notestine, Christine" uniqKey="Fennema Notestine C" first="Christine" last="Fennema-Notestine">Christine Fennema-Notestine</name><affiliation wicri:level="3"><nlm:aff id="A2">Department of Psychiatry, University of California, San Diego</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Diego</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Psychiatry, University of California</wicri:orgArea></affiliation><affiliation wicri:level="3"><nlm:aff id="A3">Department of Radiology, University of California, San Diego</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Diego</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Radiology, University of California</wicri:orgArea></affiliation></author><author><name sortKey="Grant, Michael D" sort="Grant, Michael D" uniqKey="Grant M" first="Michael D." last="Grant">Michael D. Grant</name><affiliation><nlm:aff id="A7">Department of Psychology, Boston University</nlm:aff><wicri:noCountry code="subfield">Boston University</wicri:noCountry></affiliation></author><author><name sortKey="Hauger, Richard L" sort="Hauger, Richard L" uniqKey="Hauger R" first="Richard L." last="Hauger">Richard L. Hauger</name><affiliation wicri:level="3"><nlm:aff id="A2">Department of Psychiatry, University of California, San Diego</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Diego</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Psychiatry, University of California</wicri:orgArea></affiliation></author><author><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H." last="Hellhammer">Dirk H. Hellhammer</name><affiliation wicri:level="4"><nlm:aff id="A8">Center for Psychobiological and Psychosomatic Research, University of Trier</nlm:aff><country>Allemagne</country><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName><orgName type="university">Université de Trèves</orgName></affiliation></author><author><name sortKey="Jak, Amy J" sort="Jak, Amy J" uniqKey="Jak A" first="Amy J." last="Jak">Amy J. Jak</name><affiliation wicri:level="3"><nlm:aff id="A2">Department of Psychiatry, University of California, San Diego</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Diego</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Psychiatry, University of California</wicri:orgArea></affiliation></author><author><name sortKey="Jernigan, Terry L" sort="Jernigan, Terry L" uniqKey="Jernigan T" first="Terry L." last="Jernigan">Terry L. Jernigan</name><affiliation wicri:level="3"><nlm:aff id="A2">Department of Psychiatry, University of California, San Diego</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Diego</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Psychiatry, University of California</wicri:orgArea></affiliation></author><author><name sortKey="Lupien, Sonia J" sort="Lupien, Sonia J" uniqKey="Lupien S" first="Sonia J." last="Lupien">Sonia J. Lupien</name><affiliation wicri:level="4"><nlm:aff id="A9">Department of Psychiatry, McGill University</nlm:aff><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName><orgName type="university">Université McGill</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A10">Department of Neurology and Neurosurgery, McGill University</nlm:aff><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName><orgName type="university">Université McGill</orgName></affiliation></author><author><name sortKey="Lyons, Michael J" sort="Lyons, Michael J" uniqKey="Lyons M" first="Michael J." last="Lyons">Michael J. Lyons</name><affiliation><nlm:aff id="A7">Department of Psychology, Boston University</nlm:aff><wicri:noCountry code="subfield">Boston University</wicri:noCountry></affiliation></author><author><name sortKey="Mendoza, Sally P" sort="Mendoza, Sally P" uniqKey="Mendoza S" first="Sally P." last="Mendoza">Sally P. Mendoza</name><affiliation><nlm:aff id="A11">Department of Psychology, University of California, Davis</nlm:aff><wicri:noCountry code="subfield">Davis</wicri:noCountry></affiliation></author><author><name sortKey="Neale, Michael C" sort="Neale, Michael C" uniqKey="Neale M" first="Michael C." last="Neale">Michael C. Neale</name><affiliation><nlm:aff id="A1">Department of Psychiatry, Virginia Commonwealth University</nlm:aff><wicri:noCountry code="subfield">Virginia Commonwealth University</wicri:noCountry></affiliation><affiliation><nlm:aff id="A12">Department of Human Genetics, Virginia Commonwealth University</nlm:aff><wicri:noCountry code="subfield">Virginia Commonwealth University</wicri:noCountry></affiliation></author><author><name sortKey="Seidman, Larry J" sort="Seidman, Larry J" uniqKey="Seidman L" first="Larry J." last="Seidman">Larry J. Seidman</name><affiliation wicri:level="4"><nlm:aff id="A13">Department of Psychiatry, Harvard University</nlm:aff><country>États-Unis</country><placeName><settlement type="city">Cambridge (Massachusetts)</settlement><region type="state">Massachusetts</region></placeName><orgName type="university">Université Harvard</orgName></affiliation></author><author><name sortKey="Tsuang, Ming T" sort="Tsuang, Ming T" uniqKey="Tsuang M" first="Ming T." last="Tsuang">Ming T. Tsuang</name><affiliation wicri:level="3"><nlm:aff id="A2">Department of Psychiatry, University of California, San Diego</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Diego</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Psychiatry, University of California</wicri:orgArea></affiliation><affiliation><nlm:aff id="A6">VA San Diego Health Care System</nlm:aff></affiliation><affiliation wicri:level="3"><nlm:aff id="A14">Center for Behavioral Genomics, University of California, San Diego</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Diego</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Center for Behavioral Genomics, University of California</wicri:orgArea></affiliation></author><author><name sortKey="Kremen, William S" sort="Kremen, William S" uniqKey="Kremen W" first="William S." last="Kremen">William S. Kremen</name><affiliation wicri:level="3"><nlm:aff id="A2">Department of Psychiatry, University of California, San Diego</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Diego</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Psychiatry, University of California</wicri:orgArea></affiliation><affiliation><nlm:aff id="A6">VA San Diego Health Care System</nlm:aff></affiliation><affiliation wicri:level="3"><nlm:aff id="A14">Center for Behavioral Genomics, University of California, San Diego</nlm:aff><country>États-Unis</country><placeName><settlement type="city">San Diego</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Center for Behavioral Genomics, University of California</wicri:orgArea></affiliation></author></analytic><series><title level="j">Genes, Brain, and Behavior</title><idno type="ISSN">1601-1848</idno><idno type="eISSN">1601-183X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Self-esteem and well-being are important for successful aging, and some evidence suggests that self-esteem and well-being are associated with hippocampal volume, cognition, and stress responsivity. Whereas most of this evidence is based on studies of older adults, we investigated self-esteem, well-being and hippocampal volume in 474 male middle-age twins. Self-esteem was significantly positively correlated with hippocampal volume (.09, p=.03 for left hippocampus, .10, p=.04 for right). Correlations for well-being were not significant (ps ≫.05). There were strong phenotypic correlations between self-esteem and well-being (.72, p<.001) and between left and right hippocampal volume (.72, p<.001). In multivariate genetic analyses, a 2-factor AE model with well-being and self-esteem on one factor and left and right hippocampal volumes on the other factor fit the data better than Cholesky, independent pathway or common pathway models. The correlation between the two genetic factors was .12 (p=.03); the correlation between the environmental factors was .09 (p>05). Our results indicate that largely different genetic and environmental factors underlie self-esteem and well-being on the one hand and hippocampal volume on the other.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>États-Unis</li></country><region><li>Californie</li><li>Massachusetts</li><li>Québec</li><li>Rhénanie-Palatinat</li></region><settlement><li>Cambridge (Massachusetts)</li><li>Montréal</li><li>San Diego</li><li>Trèves (Allemagne)</li></settlement><orgName><li>Université Harvard</li><li>Université McGill</li><li>Université de Trèves</li></orgName></list><tree><noCountry><name sortKey="Eyler, Lisa T" sort="Eyler, Lisa T" uniqKey="Eyler L" first="Lisa T." last="Eyler">Lisa T. Eyler</name><name sortKey="Fischl, Bruce" sort="Fischl, Bruce" uniqKey="Fischl B" first="Bruce" last="Fischl">Bruce Fischl</name><name sortKey="Grant, Michael D" sort="Grant, Michael D" uniqKey="Grant M" first="Michael D." last="Grant">Michael D. Grant</name><name sortKey="Kubarych, Thomas S" sort="Kubarych, Thomas S" uniqKey="Kubarych T" first="Thomas S." last="Kubarych">Thomas S. Kubarych</name><name sortKey="Lyons, Michael J" sort="Lyons, Michael J" uniqKey="Lyons M" first="Michael J." last="Lyons">Michael J. Lyons</name><name sortKey="Mendoza, Sally P" sort="Mendoza, Sally P" uniqKey="Mendoza S" first="Sally P." last="Mendoza">Sally P. Mendoza</name><name sortKey="Neale, Michael C" sort="Neale, Michael C" uniqKey="Neale M" first="Michael C." last="Neale">Michael C. Neale</name><name sortKey="Prom Wormley, Elizabeth C" sort="Prom Wormley, Elizabeth C" uniqKey="Prom Wormley E" first="Elizabeth C." last="Prom-Wormley">Elizabeth C. Prom-Wormley</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Franz, Carol E" sort="Franz, Carol E" uniqKey="Franz C" first="Carol E." last="Franz">Carol E. Franz</name></region><name sortKey="Dale, Anders M" sort="Dale, Anders M" uniqKey="Dale A" first="Anders M." last="Dale">Anders M. Dale</name><name sortKey="Dale, Anders M" sort="Dale, Anders M" uniqKey="Dale A" first="Anders M." last="Dale">Anders M. Dale</name><name sortKey="Fennema Notestine, Christine" sort="Fennema Notestine, Christine" uniqKey="Fennema Notestine C" first="Christine" last="Fennema-Notestine">Christine Fennema-Notestine</name><name sortKey="Fennema Notestine, Christine" sort="Fennema Notestine, Christine" uniqKey="Fennema Notestine C" first="Christine" last="Fennema-Notestine">Christine Fennema-Notestine</name><name sortKey="Franz, Carol E" sort="Franz, Carol E" uniqKey="Franz C" first="Carol E." last="Franz">Carol E. Franz</name><name sortKey="Hauger, Richard L" sort="Hauger, Richard L" uniqKey="Hauger R" first="Richard L." last="Hauger">Richard L. Hauger</name><name sortKey="Jak, Amy J" sort="Jak, Amy J" uniqKey="Jak A" first="Amy J." last="Jak">Amy J. Jak</name><name sortKey="Jernigan, Terry L" sort="Jernigan, Terry L" uniqKey="Jernigan T" first="Terry L." last="Jernigan">Terry L. Jernigan</name><name sortKey="Kremen, William S" sort="Kremen, William S" uniqKey="Kremen W" first="William S." last="Kremen">William S. Kremen</name><name sortKey="Kremen, William S" sort="Kremen, William S" uniqKey="Kremen W" first="William S." last="Kremen">William S. Kremen</name><name sortKey="Panizzon, Matthew S" sort="Panizzon, Matthew S" uniqKey="Panizzon M" first="Matthew S." last="Panizzon">Matthew S. Panizzon</name><name sortKey="Seidman, Larry J" sort="Seidman, Larry J" uniqKey="Seidman L" first="Larry J." last="Seidman">Larry J. Seidman</name><name sortKey="Tsuang, Ming T" sort="Tsuang, Ming T" uniqKey="Tsuang M" first="Ming T." last="Tsuang">Ming T. Tsuang</name><name sortKey="Tsuang, Ming T" sort="Tsuang, Ming T" uniqKey="Tsuang M" first="Ming T." last="Tsuang">Ming T. Tsuang</name></country><country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H." last="Hellhammer">Dirk H. Hellhammer</name></region></country><country name="Canada"><region name="Québec"><name sortKey="Lupien, Sonia J" sort="Lupien, Sonia J" uniqKey="Lupien S" first="Sonia J." last="Lupien">Sonia J. Lupien</name></region><name sortKey="Lupien, Sonia J" sort="Lupien, Sonia J" uniqKey="Lupien S" first="Sonia J." last="Lupien">Sonia J. Lupien</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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